HGM 2011 - Dubai, UAE
Yang Huanming - Abstract
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Henry Huanming Yang
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The International Human Genome Project (HGP) has opened the door to Personalized Medicine?, or genomic medicine, by providing the first reference sequence of our genome, as well as new concepts, strategies and powerful tools for OMICS. Even we don't have the consensus for the definition of Personalized Medicine yet, we might describe it, just practically and ideally, as to have the right diagnosis and the right medicine, at the right time, at the right dose, in the right way for the right disease of the right patient.? First of all, Personalized Medicine requires personal genome sequence as the basis and starting point. It also requires more knowledge about population-specific genome differences among all the major populations in the world (¯the human pan-genomes?), moreknowledge about evolution and adaptation of our genomes, as well as the selection by environment and our own life style. It requires more knowledge about the disease-related genome differences, especially about the heterogeneity of diseases. It requires more knowledge about the mirobes, especially pathogens, and metagenomes in different parts in our body and their variations under different conditions, about the host-microbe/pathogen interaction and host susceptibility. In addition, other -omics, such as proteomics, nutrigenomics, metabolomics, and their possible relevance to epigenomics, might be important. Personalized medicine also faces new bioethical challenges. Perhaps is the reconsideration of the ownership of a genome. |
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Sheikh Hamdan Bin Rashid Al Maktoum |
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Human Genome Organisation |
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Centre for Arab Genomic Studies |
