HGM 2011 - Dubai, UAE

Programme

Speakers

Call for Abstracts

Travel Award

Registration

Lotfi Chouchane


Title: Breast Cancer in Arab Populations: from Cancer-oriented Genomic and Proteomic Approaches towards Preventive and Predictive Medicine

Breast Cancer remains one of the leading causes of death among women worldwide. The incidence of the disease has been increasing in Arab populations. The collected data suggest that Arab women may experience an early age of onset and a preponderance of aggressive breast cancer phenotype. Particularly important is the exceptionally high prevalence of inflammatory breast cancer (IBC) in Arab populations.
The replication of the associations found between the novel SNPs and breast cancer, revealed by the recent genome-wide association studies, in populations other than Caucasians, such as Arab populations, is essential for the validation of these findings.
In this communication, I will summarize recent investigations of breast cancer candidate genes and proteins, which their variation may predict not only breast cancer onset in the Arab populations but also the clinical outcome.
The potential identification of proteins/genes associated specifically with the aggressive forms of breast cancer could shed light on the important molecular pathways of metastases and eventually could be translated into alleviate and preventing poor survival outcome of breast cancer.

Sheikh Hamdan Bin Rashid Al Maktoum
Award for Medical Science

Human Genome Organisation

Centre for Arab Genomic Studies