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BioNanomatrix, Inc has developed the world's first commercial system (nanoAnalyzerŪ 1000) for high throughput dynamic single molecule level analysis using a high density nanochannel array platform.
The core technology consists of a nanofluidic chip with thousands of massively parallel channels of less than 100 nm fabricated on the surface of a silicon chip. Long genomic DNA molecules of 100's kbs to multi-megabases can be linearly streamed continuously into these long channels and analyzed individually in a massive parallel fashion. Fluorescently labeled molecular length, sequence and chemical moiety-specific signature at genomic and epigenomic level could be imaged and correlated to a series of quantitative linear patterns at high resolution in standardized format using BioNanomatrix's nanoStudio TM and nanoMap TM software suite. This automated, high-resolution, multi-color imaging platform enables a wide range of applications, including direct single molecule level sample quality control, direct DNA damage and chemical modification assessment, accurate genome finishing and assembly, and DNA structural variation analysis associated with diseases, such as cancer.
The unprecedented dynamic access to long genomic segments provided by nanoAnalyzerŪ 1000 system for linearizing and imaging intact native DNA in solution, with the planned affordability, speed and simplicity of the technology is expected to make the routine use of genetic information feasible in broad-ranging applications impacting molecular diagnostics, personalized medicine and daily biomedical research. |
